Most trial systems manage stages. PRISM governs the movement between them.Every patient advances on readiness evidence, not quotas, clicks, or assumptions.Six stages. Four connected layers. One operating system built for completion.
Every trial has six decision points. Vendors touch some. PRISM governs all six through unified readiness logic that advances patients by evidence instead of volume.
Calling PRISM an operating system describes what the architecture does. It governs transitions between stages, enforces readiness criteria at every point, and maintains accountability from first interaction through final visit.
Most models treat stages as sequential steps. PRISM treats them as governed transitions. Step models advance patients because the process demands movement. PRISM advances patients when readiness evidence justifies it.
Prepares patients to evaluate participation in the context of their daily life, not just protocol details. Education disconnected from real-world feasibility produces regret after enrollment.
Engages caregivers as feasibility partners and decision influencers, not passive observers. Household-level feasibility is an overlooked retention driver that surfaces mid-trial when it is too late.
Surfaces time, procedures, logistics, and disruption early. Surprises are expensive. Regret and misalignment after enrollment are preventable when expectation calibration happens before consent, not during it.
Structures information to match how people process complex decisions, reducing cognitive overload and false confidence. False confidence at consent often becomes disengagement by visit three.
Reinforces understanding as burden and uncertainty accumulate. Static PDFs fail under dynamic pressure. Education must persist across the lifecycle, not stop after consent.
Addresses fear, uncertainty, and anxiety before they undermine trust and commitment. Fear is a silent attrition variable. It does not appear in eligibility data, but it drives withdrawal decisions.
Each stage is a decision point. Between every stage, PRISM evaluates whether readiness evidence justifies advancement. Unready patients get targeted development. Ready patients advance with validated context. No stages skipped. No automatic transitions.
The question this stage answers: Who in the population could qualify for this trial, which sites are best positioned to run it, and does the protocol itself create avoidable friction?
Identification is first, but in most models it is also the last point of rigor. Traditional identification stops at diagnosis codes and demographics. It finds eligible patients. It reveals nothing about engagement, consent, or persistence. It ignores site capability. It never questions whether the protocol design itself introduces barriers.
PRISM fuses claims, EMR/EHR, lab values, SDOH, and BDOH into multidimensional profiles that model who will complete, not just who qualifies. Clinical fit integrates with social context and behavioral patterns to predict activation durability and flag early dropout risk before enrollment begins. These predictive insights trigger readiness interventions from the start.
PRISM also identifies optimal sites by analyzing real-world data on catchment demographics, historical performance, and capacity. And it surfaces protocol-level friction, enabling sponsors to author or amend protocols informed by readiness intelligence before a single patient is enrolled.
What makes this different: Most platforms stop after eligibility. PRISM models propensity to respond, enroll, and finish. It evaluates site readiness. It feeds protocol design with real-world evidence. Stage 2 assessment does not start from zero.
The question this stage answers: Where will friction emerge for this specific patient?
Eligibility asks one binary question. Readiness assessment asks the questions that predict outcomes: Can this patient get to the site? Does the patient understand commitment? Is their support system stable enough? Will burden overwhelm motivation?
PRISM maps three friction dimensions for every patient. Structural: logistics, transportation, scheduling, finances. Cognitive: health literacy, protocol comprehension, expectation gaps. Behavioral: motivation stability, caregiver dynamics, competing priorities, historical compliance.
The output is not a single readiness score. It is a friction profile that tells the system exactly where intervention is needed, what kind of intervention will work, and how much readiness development is required before this patient should advance.
The question this stage answers: What support do patients need to move forward?
Traditional lead scoring ranks individuals by likelihood to engage. We take a different approach: grouping patients into segments based on shared friction patterns and behavioral signals, then matching each segment with the right level of support.
Eagerness without understanding causes screen failures. Enthusiasm without burden awareness causes dropouts. We segment by shared readiness needs, not by how close someone is to converting.
Each segment gets an appropriate readiness strategy. Segments facing fewer barriers move through with lighter support. Segments with moderate friction get targeted development. Segments with significant friction get intensive support until barriers are addressed. No permanent exclusions. No quota-driven advancement.
The question this stage answers: What readiness work does each patient actually need?
Stage 4 activates PRISM's experience layer. Every patient gets education tailored to friction and segment. Cognitive barriers get comprehension content. Structural barriers get logistics and burden calibration. Behavioral friction gets expectation alignment and caregiver integration.
Engagement starts with channel preference. PRISM reaches patients via digital, social, and direct channels. HCP outreach and EMR matching drive informed, high-intent referrals. Activation is prioritized by readiness, not volume.
Multiple connectivity pathways lower friction. In-ad conversational units embedded in digital and social placements enable immediate qualification without redirect friction. Physical materials include 2D barcodes routing patients into guided readiness workflows. Interaction options span conversational agent, AI-driven voice calls, and SMS.
Real-time support lowers decision investment. PRISM breaks complex protocol information into adaptive dialogue that reduces cognitive overload. It responds to hesitation, fear, and feasibility concerns in real time, personalized by medical, contextual, and behavioral signals. Uncertainty converts into informed commitment.
This is where CORE operates within PRISM. When education gaps emerge, PRISM draws from CORE's 115+ asset formats. PRISM governs sequencing. CORE supplies content.
Engagement measures comprehension, expectation alignment, and decision readiness. Patients advance only when evidence meets the pre-screening threshold.
The question this stage answers: Is this patient both eligible and ready to proceed to site-level screening?
Traditional pre-screening confirms eligibility. PRISM pre-screening confirms both eligibility and readiness. The economic truth: every screen-failed patient costs time, money, and staff attention that cannot be recovered.
PRISM's conversational AI validates eligibility, confirms comprehension, checks logistics, and assesses motivation. It also detects hesitation, confusion, and feasibility friction in real time, adapting the dialogue before screening proceeds.
When barriers surface, PRISM provides guided resolution rather than defaulting to exclusion. This stabilizes readiness before site handoff and prevents avoidable false starts. Patients who clear pre-screening understand burden and commitment. Questions are answered. Support is in place.
Screen failure prevention happens here, not at the site.
The question this stage answers: Does the site have everything it needs to onboard this patient without starting from scratch?
In standard models, handoff breaks accountability. A vendor delivers a name. The site starts from zero: re-explaining, re-assessing, managing confusion that should have been resolved. The site becomes both educator and executor, neither role sufficient.
PRISM delivers a prepared patient with validated context. The site knows what the patient understands, where concerns lie, what logistics are in place, what support exists. The patient arrives having worked through questions, fears, and expectations. The site's first interaction confirms, not introduces.
PRISM reduces site burden without removing site control. Clinical decisions stay with the site. But 40-60% of coordinator time spent on prep work is already done, validated, and documented.
Stages describe when. Layers describe how. Each layer spans the full lifecycle from identification through completion. Together they form the operating system.
Five transitions connect six stages. Each has defined readiness criteria. Meeting criteria advances with context. Not meeting them triggers targeted development. Patients unable to achieve readiness are held, not abandoned.
1-to-2: Eligibility confirmed, data foundation set. Readiness assessment begins.
2-to-3: Friction profile complete. Ranking incorporates readiness alongside clinical data.
3-to-4: Segment assigned, intervention path defined. Engagement matches actual needs, not generic tracks.
4-to-5: Comprehension, expectation alignment, burden understanding validated. Ready for pre-screening, not just willing.
5-to-6: Both eligibility and readiness confirmed. Site gets a prepared patient with context, not a cold referral.
Identify, Assess Readiness, Segment & Support, Engage & Educate, Pre-screen, and Hand Off to Sites. Each transition is governed by readiness evidence, not volume targets.
Data Layer for multi-source intelligence. Experience Layer for segment-tailored education. Coordination Layer with agentic AI. Measurement Layer with three live indices (PXCI, IEQS, CRI).
A decision point where readiness evidence determines advancement. Patients not meeting criteria get targeted development, not automatic forward motion.
Gradual erosion of a patient's capacity or willingness to continue: declining engagement, burden accumulation, caregiver destabilization. PRISM distinguishes temporary friction from systematic decay and surfaces proportionate recommended responses for the sponsor's team.
Prevention happens in Stage 5, not at the site. PRISM validates both eligibility and readiness before handoff. Sites get prepared patients, not unqualified referrals.
CORE operates in PRISM's Experience Layer, primarily Stage 4. When education gaps emerge, PRISM surfaces CORE assets as resources, adapted by segment and readiness profile.
Proprietary constructs defined by Jumo Health. Each one is a measurable operational concept, not a marketing term. View all definitions →
In two days, you get three execution diagnostics on your program.
How likely each eligible patient cluster is to activate, persist, and complete, before any intervention.
The barriers most likely to suppress activation, enrollment, and completion in each cluster, and how to mitigate them.
Which clusters to target, which barriers to address, which interventions to deploy, and what completion lift to expect.